# US 2010/0137330 A1 · Use

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- Number: US 2010/0137330 A1
- Document ID: US20100137330A1
- Status: Published application
- Kind: A1
- Application number: 12/539,858
- Filed: 2009-08-12
- Published: 2010-06-03
- Earliest claimed: 2007-03-08
- Inventors: Ratan Bhat; Anna-Lena Berg
- Web page: https://patentgrep.com/patent/US20100137330A1

## CPC

- A61K 31/497: containing further heterocyclic rings
- A61K 31/551: having two nitrogen atoms, e.g. dilazep
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to a new use of a compound of the formula (I) wherein R1 is NH2, piperazin-1-yl, 4-methylpiperazin-1-yl, 4-methyl-1,4-diazepan-1-yl or 4-ethylpiperazin-1-yl; R2 is hydrogen, fluoro, CH3, CH2CH3, OCH3, CF3 or OCF3; R3 is hydrogen, CH3 or fluoro; as a free base or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the prevention and/or treatment of bone-related disorders, osteoporosis and increasing bone formation, bone mineral density. The present invention further relates to a method of prevention and/or treatment of these disorders.

## Claims

### Claim at position 1

1-24. (canceled)

### Claim 25

A method of prevention and/or treatment of bone-related disorders or conditions comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that is 3-amino-6-(4-piperazin-1-ylsulfonylphenyl)-N-pyridin-3-ylpyrazine-2-carboxamide or of a pharmaceutically acceptable salt thereof.

### Claim 26 (depends on 25)

A method of prevention and/or treatment according to claim 25 wherein said bone-related disorder or condition is osteoporosis.

### Claim 27 (depends on 25)

A method of prevention and/or treatment according to claim 25 wherein said treatment comprises increasing bone formation.

### Claim 28 (depends on 25)

A method of prevention and/or treatment according to claim 25 wherein said treatment comprises increasing cancellous bone formation and/or increasing new bone formation.

### Claim 29 (depends on 25)

A method of prevention and/or treatment according to claim 25 wherein said treatment comprises increasing bone mineral density.

### Claim 30 (depends on 25)

A method of prevention and/or treatment according to claim 25 wherein said treatment comprises reducing the incidence of fracture.

### Claim 31 (depends on 25)

A method according to claim 25, wherein said mammal is a human.

### Claim 32 (depends on 26)

A method according to claim 26, wherein said mammal is a human.

### Claim 33 (depends on 27)

A method according to claim 27, wherein said mammal is a human.

### Claim 34 (depends on 28)

A method according to claim 28, wherein said mammal is a human.

### Claim 35 (depends on 29)

A method according to claim 29, wherein said mammal is a human.

### Claim 36 (depends on 30)

A method according to claim 30, wherein said mammal is a human.