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US 2010/0137327 A1Published application
Novel semicarbazide and carbonylhydrazide derivatives useful as potassium channel modulators
AssigneeNeuroSearch A/S
InventorsAntonio Nardi, Joachim Demnitz, Morten Grunnet, Palle Christophersen, David Spencer Jones, Elsebet Østergaard Nielsen, Dorte Strøbæk, Lars Siim Madsen
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Abstract
This invention relates to novel semicarbazide and carbonylhydrazide derivatives that are found to be potent modulators of potassium channels and, as such, they are valuable candidates for the treatment of diseases or disorders as diverse as those which are responsive to modulation of potassium channels.
Claims14
1-16. (canceled)
A semicarbazide or carbonylhydrazide derivative of Formula I
- an enantiomer or a mixture of its enantiomers, or a pharmaceutically-acceptable addition salt thereof wherein
- X may be absent (representing a covalent bond) or may represent NH;
- R1 represents a tetrazolyl group;
- R2 represents halo, hydroxy or phenyl, which phenyl is optionally substituted one or more times with halo and/or trifluoromethyl;
- and
- R3 and R4, independently of each other, represent halo, trifluoromethyl, hydroxy and/or phenyl.
3 more elements
Dependencies are inferred from the claim text.