Bicyclic heterocyclic compound
AssigneeOno Pharmaceutical Co., Ltd.
InventorsTetsuji Saito, Tetsuo Obitsu, Yoshifumi Kagamiishi
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Abstract
A compound of a formula (I): wherein R1 represents a C3-10 branched alkyl group which may be substituted; R2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted; R3 represents a C1-4 alkyl group which may be substituted or a halogen atom; R4 represents a C1-4 alkyl group which may be substituted; and ring 1 represents a cyclic group which has planarity and may have a substituent group, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a medicinal component having CRF antagonistic activity for the prevention and/or treatment of a neuropsychiatric disease, a peripheral organ disease and the like.
Claims18
A compound of a formula (I):
- wherein R1 represents (1) a C3-10 branched alkyl group which may be substituted or (2) a —(CH2)m—NR5R6 group;
- R5 and R6 each independently represent a C1-6 alkyl group which may be substituted, or R5 represents a hydrogen atom and R6 represents a C3-6 branched alkyl group which may be substituted;
- m represents 0 or an integer of 1 to 3;
- R2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted;
- R3 represents a C1-4 alkyl group which may be substituted or a halogen atom;
- R4 represents a C1-4 alkyl group which may be substituted or a C3-6 cycloalkyl group which may be substituted;
- and
- ring 1 represents a cyclic group which has planarity and may have a substituent group,
- a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof.
(canceled)
Dependencies are inferred from the claim text.