Fused Thiazole Derivatives as Kinase Inhibitors

A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof:

• wherein
• X represents oxygen or sulphur;
• Y represents a group of formula CR6R7 or NR8;
• R1 represents hydrogen or C1-6 alkyl;
• and
• R2 represents hydrogen;
• or C1-6 alkyl, C1-6 alkoxy, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• or
• R1 and R2, when taken together with the carbon atom to which they are both attached, represent C3-7 cycloalkyl or C3-7 heterocycloalkyl, either of which groups may be optionally substituted by one or more substituents;
• R3 and R4 independently represent hydrogen;
• or C1-6 alkyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, aryl(C2-6)alkenyl, aryl(C2-6)-alkynyl, biaryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, C3-7 heterocycloalkylcarbonyl, heteroaryl, heteroaryl(C1-6)alkyl, heteroaryl-aryl(C1-6)alkyl or arylheteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• or
• R3 and R4, when both are attached to the same carbon atom, represent, when taken together with the carbon atom to which they are both attached, C3-7 cycloalkyl or C3-7 heterocycloalkyl, either of which groups may be optionally substituted by one or more substituents;
• or
• R3 and R4, when attached to adjacent carbon atoms, represent, when taken together with the carbon atoms to which they are attached, C5-7 cycloalkyl, phenyl or heteroaryl, any of which groups may be optionally benzo-fused and/or substituted by one or more substituents;
• R5 represents hydrogen or C1-6 alkyl;
• R6 represents hydrogen;
• or C1-6 alkyl, C1-6 alkoxy, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• and
• R7 represents hydrogen or C1-6 alkyl;
• or
• R6 and R7, when taken together with the carbon atom to which they are both attached, represent C3-7 cycloalkyl or C3-7 heterocycloalkyl, either of which groups may be optionally substituted by one or more substituents;
• or
• R2 and R6, when taken together with the carbon atoms to which they are attached, represent C5-7 cycloalkyl, phenyl or heteroaryl, any of which groups may be optionally benzo-fused and/or substituted by one or more substituents;
• and
• R8 represents hydrogen;
• or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• or
• R2 and R8, when taken together with the carbon and nitrogen atoms to which they are respectively attached, represent C5-7 heterocycloalkyl or heteroaryl, either of which groups may be optionally benzo-fused and/or substituted by one or more substituents.