Substituted Indolealkanoic Acids

A compound of the formula:

• wherein
• A is a C1-C4 alkylene group optionally substituted with C1-C2 alkyl or mono- or disubstituted with halogen;
• Z is a bond, O, S, C(O)NH, or C1-C3 alkylene optionally substituted with C1-C2 alkyl;
• R1 is hydrogen, alkyl having 1-6 carbon atoms, halogen, 2-, 3-, or 4-pyridyl, or phenyl, where the phenyl or pyridyl is optionally substituted with up to three groups selected from halogen, hydroxy, C1-C6 alkoxy, C1-C6 alkyl, nitro, amino, or mono- or di(C1-C6)alkylamino;
• R2, R3, R4 and R5 are each independently
• hydrogen, halogen, nitro, or an alkyl group of 1-6 carbon atoms optionally substituted with one or more halogens;
• OR7, SR7, S(O)R7, S(O)2N(R7)2, C(O)N(R7)2, or N(R7)2, wherein each R7 is independently hydrogen, an alkyl group of 1-6 carbon atoms optionally substituted with one or more halogens, or benzyl, where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C2-C6 alkyl, C1-C6 alkoxy, amino, and mono- or di(C2-C6)alkylamino;
• phenyl or heteroaryl, where each of which phenyl or heteroaryl is optionally substituted with up to three groups independently selected from halogen, C2-C6 alkyl, C1-C6 alkoxy, amino, and mono- or di(C2-C6)alkylamino;
• phenoxy where the phenyl portion is optionally substituted with up to three groups independently selected from halogen, C2-C6 alkyl, C2-C6 alkoxy, amino, and mono- or di(C2-C6)alkylamino;
• or
• a group of the formula
• where
• J is a bond, CH2, oxygen, or nitrogen;
• and
• each r is independently 2 or 3;
• R6 is hydroxy, benzyloxy, di(C2-C6)alkylaminoethyloxy, acetoxymethyl, pivaloyloxymethyl, phthalidoyl, ethoxycarbonyloxyethyl, 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl, C1-C6 alkoxy or O−M+ where M+ represents a cation selected from sodium, potassium, ammonium, magnesium and calcium;
• Ra is hydrogen, C1-C6 alkyl, fluoro, or trifluoromethyl;
• and Ar represents
• a heterocyclic 5-membered ring having one nitrogen, oxygen or sulfur, two nitrogens one of which may be replaced by oxygen or sulfur, or three nitrogens one of which may be replaced by oxygen or sulfur, said heterocyclic 5-membered ring substituted being condensed with benzo, said benzo being optionally substituted by one of iodo, cyano, nitro, perfluoroethyl, trifluoroacetyl, or (C1-C6)alkanoyl, one or two of fluoro, chloro, bromo, hydroxy, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, trifluoromethoxy, trifluoromethylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl or trifluoromethyl, or two fluoro or two trifluoromethyl with one hydroxy or one (C1-C6)alkoxy, or one or, preferably, two fluoro and one trifluoromethyl, or three fluoro;
• a heterocyclic 6-membered ring having one to three nitrogen atoms, or one or two nitrogen atoms and one oxygen or sulfur, said heterocyclic 6-membered ring being condensed with benzo, where the benzo is optionally substituted by one of iodo or trifluoromethylthio, or one or two of fluoro, chloro, bromo, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkylthio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, or trifluoromethyl;
• said benzo-condensed heterocyclic 5-membered or 6-membered rings being optionally substituted in the heterocyclic 5-membered or 6-membered ring by one of fluoro, chloro, bromo, methoxy, or trifluoromethyl.