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US 2010/0137274 A1Published application
Substituted oxazolidinones and their use in the field of blood coagulation
AssigneeBayer Schering Pharma Aktiengesellschaft
InventorsAlexander Straub, Thomas Lampe, Jens Pohlmann, Susanne Rohrig, Elisabeth Perzborn, Karl-Heinz Schlemmer, Joseph Pernerstorfer
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Abstract
The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.
Claims15
Compounds of the general formula (I)
- in which:
- R1 represents optionally benzo-fused thiophene (thienyl) which may optionally be mono- or polysubstituted;
- R2 represents any organic radical;
- R3, R4, R5, R6, R7 and R8 are identical or different and each represents hydrogen or represents (C1-C6)-alkyl
- and their pharmaceutically acceptable salts, hydrates and prodrugs,
- except for compounds of the general formula (I) in which the radical R1 is an unsubstituted 2-thiophene radical and the radical R2 is simultaneously a mono- or polysubstituted phenyl radical and the radicals R3, R4, R5, R6, R7 and R8 are each simultaneously hydrogen.
3 more elements
Use of compounds of the general formula (I)
- in which:
- R1 represents optionally benzo-fused thiophene (thienyl) which may optionally be mono- or polysubstituted;
- R2 represents any organic radical;
- R3, R4, R5, R6, R7 and R8 are identical or different and each represents hydrogen or represents (C1-C6)-alkyl
- and their pharmaceutically acceptable salts, hydrates and prodrugs,
- for preparing medicaments or pharmaceutical compositions for the prophylaxis and/or treatment of thromboembolic disorders, in particular myocardial infarct, angina pectoris (including unstable angina), reocclusions and restenoses after angioplasty or aorto-coronary bypass, stroke, transitory ischaemic attacks, peripheral arterial occlusive diseases, pulmonary embolisms or deep venous thromboses.
3 more elements
Dependencies are inferred from the claim text.