Progestational 3-(6,6-ethylene-17b-hydroxy-3-oxo-17a-pregna-4-ene-17a-yl)propionic acid g-lactones
AssigneeEvestra, Inc.
InventorsKlaus Nickisch, Pemmaraju Rao, Kesavaram Narkunan, James Cessac
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Abstract
Described herein are 3-(6,6-ethylene-17β-hydroxy-3-oxo-17α-pregna-4-ene-17α-yl)propionic acid γ-lactone derivatives having progestational and aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.
Claims16
A progestogen compound having the structure of formula (II):
- where the dotted line in Formula II represents a double bond between carbons 9 and 11 or a double bond between carbons 11 and 12;
- R1 and R2 are hydrogens, an additional bond between carbons 1 and 2, or a —CH2— bridge between carbons 1 and 2;
- and
- R3 and R4 are hydrogens or a —CH2— bridge between carbons 15 and 16.
A method of producing a contraceptive state in a subject comprising administering to a subject an oral dosage form comprising an effective amount of a progestogen compound having the structure of formula (II):
- where the dotted line in Formula II represents a double bond between carbons 9 and 11 or a double bond between carbons 11 and 12;
- R1 and R2 are hydrogens, an additional bond between carbons 1 and 2, or a —CH2— bridge between carbons 1 and 2;
- and
- R3 and R4 are hydrogens or a —CH2— bridge between carbons 15 and 16.
A progestogen compound having the structure of formula (V):
- wherein R1 and R2 are hydrogens, an additional bond between carbons 1 and 2, or a —CH2-bridge between carbons 1 and 2;
- and
- wherein R3 and R4 are hydrogens or a —CH2— bridge between carbons 15 and 16.
A method of producing a contraceptive state in a subject comprising administering to a subject an oral dosage form comprising an effective amount of a progestogen compound having the structure of formula (V):
- wherein R1 and R2 are hydrogens, an additional bond between carbons 1 and 2, or a —CH2-bridge between carbons 1 and 2;
- and
- wherein R3 and R4 are hydrogens or a —CH2— bridge between carbons 15 and 16.
Dependencies are inferred from the claim text.