Naphthylacetic acids

A compound of formula I:

• or a pharmaceutically acceptable salt or ester thereof, wherein:
• Q is C(H) or N;
• X is selected from the group consisting of:
• (1) C(O),
• (2) C(H)(H),
• (3) C(H)(OH),
• (4) C(F)(F),
• (5) C(H)(O—CH3), and
• (6) C(H)(CH3);
• R1 and R2, independently of each other, are selected from the group consisting of:
• (1) hydrogen,
• (2) halogen,
• (3) lower alkyl, optionally substituted by halogen, and
• (4) lower alkoxy,
• or alternatively, R1 and R2 are bonded together to form methylenedioxy;
• R3 is selected from the group consisting of:
• (1) hydrogen,
• (2) halogen,
• (3) lower alkyl, optionally substituted by halogen,
• (4) lower alkoxy, and
• (5) cyano;
• R4 is selected from the group consisting of:
• (1) halogen,
• (2) lower alkyl optionally substituted by halogen,
• (3) lower cycloalkyl,
• (4) lower alkoxy optionally substituted by halogen,
• (5) lower alkoxycarbonyl,
• (6) benzyloxy or benzylsulfanyl,
• (7) heteroaryl optionally substituted by lower alkyl,
• (8) cyano,
• (9) phenyl optionally substituted by methanesulfonyl,
• (10) lower alkanesulfonylmethyl, and
• (11) S(O)2—R7 wherein R7 is selected from the group consisting of:
• (a) lower alkyl optionally substituted by halogen or phenyl,
• (b) amino,
• (c) lower alkylamino,
• (d) lower dialkylamino,
• (e) acetylamino,
• (f) N-acetyl-N-lower alkylamino,
• (g) lower heterocycloalkyl optionally substituted by a substituent selected from the group consisting of:
• (i) lower alkyl,
• (ii) phenyl optionally substituted by halogen, and
• (iii) lower alkoxycarbonyl;
• and
• (h) phenyl or benzyl, wherein said phenyl or benzyl is optionally substituted by halogen or trifluoromethyl;
• and
• R5 and R6, independently of each other, are hydrogen or methyl.