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AssigneeGeorgia State University Research Foundation, Inc.
InventorsBinghe Wang, Nanting Ni, Junfeng Wang, Chung-Dar Lu, Han-Ting Chou, Minyong Li, Shilong Zheng, Yunfeng Cheng, Hanjing Peng
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The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
A compound, wherein the compound is an antagonist of a microbial quorum sensing activity, wherein the antagonist is selected from the group consisting of the formulas:
A composition for modulating quorum sensing in a microbial population, comprising:
A method for modulating a physiological activity of a microbial population, comprising:
A method of modulating biofilm formation on a surface, comprising:
A method for identifying an antagonist of the AI-2 bacterial quorum sensing system, comprising:
Dependencies are inferred from the claim text.