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US 2010/0137230 A1Published application
New pyridin-2-one compounds
OwnerLutz Weberinventor
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of the formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
Claims13
A compound having the structural formula (I)
- and its stereoisomers or its pharmacologically acceptable salt, solvate, hydrate, or formulation thereof,
- wherein
- R1 is H or F;
- and
- R2 is an alkyl group, an alkenyl group, an alkynyl group, a heteroalkyl group, a cycloalkyl group, a heterocyclo-alkyl group, an aryl group, a heteroaryl group, an alkyl-aryl group or a heteroarylalkyl group;
- all of which may be substituted with one, two or more halogen atoms like F or Cl or hydroxy or amino groups;
- and
- R3 is an azido, or a C1-6-heteroalkyl group, a heteroarylalkyl group, a heteroarylcycloalkyl group or a heteroalkylheteroaryl group;
- and
- A is a single bond, O, S, S(═O), SO2 or an alkylene group, an alkenylene group, an alkynylene group, a heteroalkylene group, a cycloalkylene group, a heterocycloalkylene group, an arylene group or a heteroarylene group all of which groups may be substituted;
- and
- B and C are independent from each other alkylene, alkenylene, alkynylene or heteroalkylene, whereby Q-B—N—C are forming together a heterocycloalkyl group or a bicyclic heterocycloalkyl group, all of these groups may be substituted with one or more R4 groups;
- and
- Q is CR4 or N;
- and
- X is CR5 or N;
- and
- Y is CH, CF or N;
- and
- R4 is H, OR6, a group of formula —OPO3R62 or —OSO3R6 or an alkyl group or a heteroalkyl group carrying one or more OR6, —OPO3R62 or —OSO3R6 group(s), wherein the groups R6 independently of each other are H, an ether or an ester of a natural or unnatural, substituted or unsubstituted monosaccharide, a natural or unnatural, substituted or unsubstituted disaccharide, a natural or unnatural, substituted or unsubstituted oligosaccharide or a natural or unnatural, substituted or unsubstituted polysaccharide.
- R5 is H, CH3, OCH3, F, Cl, OH, NH2, —CN, an alkyl group or a heteroalkyl group, and
- R2 and R5 can be linked via an alkylene, an alkenylene or a heteroalkylene group or be a part of a cycloalkylene or heterocycloalkylene group, in case R2 is not H and R5 is not H, CH3, OCH3, F, Cl, OH, NH2, —CN;
- or a pharmacologically acceptable salt, solvate, hydrate or formulation thereof.
20 more elements
Dependencies are inferred from the claim text.