Methods and compositions for intra-articular coagulation proteins

A method of controlling bleeding and/or reducing bleeding-associated joint damage in a joint of a subject, comprising delivering an effective amount of a clotting factor protein or an active fragment thereof to a joint space of the subject, thereby controlling bleeding and/or protecting from further bleeding in the joint of the subject.

A method of treating a blood clotting factor disorder in a subject, comprising delivering an effective amount of a nucleic acid encoding a clotting factor protein or an active fragment thereof to a joint space of the subject, thereby treating the blood clotting factor disorder in the subject.

A method of controlling bleeding and/or reducing bleeding-associated joint damage in a joint of a subject, comprising delivering an effective amount of a nucleic acid encoding a clotting factor protein or an active fragment thereof to a joint space of the subject, thereby controlling bleeding in the joint space of the subject.

A method of treating or preventing hemophilic arthropathy or bleeding-associated joint damage in a subject, comprising delivering an effective amount of a clotting factor protein or an active fragment thereof to a joint space of the subject, thereby treating or reducing hemophilic arthropathy or bleeding-associated joint damage in the subject.

A method of treating or preventing hemophilic arthropathy or bleeding-associated joint damage in a subject, comprising delivering an effective amount of a nucleic acid encoding a clotting factor protein or an active fragment thereof to a joint space of the subject, thereby treating or reducing hemophilic arthropathy or bleeding-associated joint damage in the subject.

A composition comprising a clotting factor or active fragment thereof and a nucleic acid encoding a clotting factor protein or active fragment thereof, in a pharmaceutically acceptable carrier.

A composition comprising a clotting factor protein or active fragment thereof and an anti-inflammatory agent, a cytokine, an immune modulator, or any combination thereof, in a pharmaceutically acceptable carrier.

A composition comprising a nucleic acid encoding a clotting factor protein or active fragment thereof and a nucleic acid encoding an anti-inflammatory agent, a cytokine, an immune modulator, or any combination thereof, in a pharmaceutically acceptable carrier.