Gastrointestinal proliferative foctor and uses thereof
AssigneesNuvelo, Inc., Kyowa Hakko Kirin Co., Ltd.
InventorsWalter Funk, Makoto Kakitani, Takeshi Oshima, Eun Ju Park, Mikio Yagi, Kazuma Tomizuka
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Abstract
The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor (GIPF) polynucleotides and polypeptides. The invention further relates to the therapeutic use of GIPF to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
Claims15
A method of stimulating epithelial cell proliferation in a mammalian subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising a polypeptide with epithelial cell proliferation stimulating activity, wherein said polypeptide comprises (i) an amino acid sequence with at least 90% sequence identity to the amino acid sequence of SEQ ID NO:4, or (ii) a fragment thereof.
A method of treating a gastrointestinal disorder or oral mucosal disorder in a mammalian subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising a polypeptide with epithelial cell proliferation stimulating activity, wherein said polypeptide comprises (i) an amino acid sequence with at least 90% sequence identity to the amino acid sequence of SEQ ID NO:4, or (ii) a fragment thereof.
Dependencies are inferred from the claim text.