Compositions and methods for treating or ameliorating mycobacterial infections
OwnerLeland Shapiroinventor
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Abstract
A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram poitive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to modulation of cellular activities, including macrophage activity, and the like. More particularly, the present invention relates to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease.
Claims20
A method for treating a disorder caused by Mycobacterium in a subject comprising:
- administering a therapeutically effective amount of a composition comprising mammalian α1-antitrypsin or derivative thereof to the subject.
A method for ameliorating macrophage infection in a subject by a mycobacterium avium complex (mac), comprising administering a therapeutically effective amount of a composition comprising mammalian α1-antitrypsin or derivative thereof to the subject exposed to mycobacterium avium complex (mac).
A method for ameliorating the onset of a Mycobacterium tuberculosis or Mycobacterium bovis infection in a subject comprising, administering a therapeutically effective amount of a composition comprising mammalian α1-antitrypsin or derivative thereof to the subject.
A method for ameliorating Mycobacterium tuberculosis or Mycobacterium bovis infection in a subject comprising, administering a therapeutically effective amount of a composition comprising one or more peptides selected from the group consisting of AGAMFLEAIP (SEQUENCE ID NO. 56);
- MSIPPEVKFN (SEQUENCE ID NO. 57);
- KPFVFLMIEQ (SEQUENCE ID NO. 58);
- NTKSPLFMGK (SEQUENCE ID NO. 59);
- and combinations thereof to the subject.
A method for treating a Mycobacterium infection of the lungs in a patient comprising:
- administering a therapeutically effective amount of a composition comprising mammalian α1-antitrypsin or derivative thereof to the patient.
A method for treating latent TB (LTBI) infection in a patient comprising:
- administering a therapeutically effective amount of a composition comprising mammalian α1-antitrypsin or derivative thereof to the patient.
Dependencies are inferred from the claim text.