Glutamate-Enhanced Cell-Penetrating Peptides and Methods of Using Same
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsBeverly E. Barton, H. Dan Lewis, Robert J. Donnelly, Ali Husain, Dimitrios Barlos, Sheraz Riaz
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Abstract
Disclosed herein are novel glutamate-enhanced cell-penetrating peptides (CPPs) for use as delivery vehicles to mediate intracellular uptake of therapeutic payloads and methods of using the same.
Claims20
A cell-penetrating peptide comprising a glutamate peptide bound to a NLS peptide by a linker.
A method of inducing apoptosis in a cell comprising incubating a colony of said cells with a cell-penetrating peptide comprising a glutamate peptide bound to a NLS peptide by a linker.
A composition comprising a cell-penetrating peptide and a STAT3-inhibiting therapeutic payload.
Dependencies are inferred from the claim text.