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US 2010/0137154 A1Published application
Genome analysis using a methyltransferase
OwnerRobert A. Ach, Brian J. Peterinventors
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Abstract
A method of genome analysis is provided. In certain embodiments, the method may comprise: labeling the test genome using a first site-specific methyltransferase to produce a labeled test genome comprising a label; and analyzing the labeled test genome to determine if the test genome comprises a sequence alteration relative to a reference sequence. In certain embodiments, the method may comprise: evaluating binding of the labeled test genome to an array of probes, or observing a pattern of labeling along the labeled test genome.
Claims20
A method of analyzing a test mammalian genome comprising:
- a) labeling a nucleic acid of said test mammalian genome using a first site-specific methyltransferase to produce a labeled nucleic acid comprising a label;
- b) analyzing said labeled nucleic acid test to determine if said test mammalian genome comprises a chromosomal rearrangement or a different allele of a SNP relative to a reference mammalian sequence.
Dependencies are inferred from the claim text.