Natural IgM Antibodies
OwnerMichael C. Carroll, Francis D. Moore, JR. +1inventors
InventorsMichael C. Carroll, Francis D. Moore, JR., Herbert B. Hechtman
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Abstract
The invention provides natural IgM antibodies that may be used to induce inflammatory diseases or disorders such as ischemia-reperfusion injury to create animal models of such inflammatory diseases or disorders.
Claims14
An isolated antibody or antigen binding fragment thereof which specifically binds to an ischemic antigen, wherein the antibody or antigen binding fragment thereof comprises:
- a) an amino acid sequence comprising the variable heavy (VH) complementary determining region (CDR) 1 of SEQ ID NO:2;
- b) an amino acid sequence comprising the VH CDR2 of SEQ ID NO:2;
- c) an amino acid sequence comprising the VH CDR3 of SEQ ID NO:2;
- d) an amino acid sequence comprising the variable light (VL) CDR1 of SEQ ID NO:8;
- e) an amino acid sequence comprising the VL CDR2 of SEQ ID NO:8;
- and
- f) an amino acid sequence comprising the VL CDR3 of SEQ ID NO:8.
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 8, SEQ ID NO:
- 10, SEQ ID NO:
- 12, and SEQ ID NO:16, which specifically binds to an ischemic antigen.
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule comprising a nucleotide sequence which is at least 98% identical to the nucleotide sequence of SEQ ID NO:
- 7, SEQ ID NO:
- 9, SEQ ID NO:
- 11, or SEQ ID NO:15;
- and
- b) a nucleic acid molecule which hybridizes to the nucleotide sequence of SEQ ID NO:
- 7, SEQ ID NO:
- 9, SEQ ID NO:
- 11, or SEQ ID NO:15 under stringent conditions.
Dependencies are inferred from the claim text.