Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
AssigneeGenentech, Inc.
InventorsAvi J. Ashkenazi, Anan Chuntharapai, K. Jin Kim
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Abstract
A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.
Claims21
An isolated nucleic acid comprising DNA encoding an antibody which specifically cross-reacts with two or more different Apo-2L receptors.
An isolated nucleic acid comprising DNA encoding an antibody having the biological characteristics of a monoclonal antibody selected from the group consisting of 3H1.18.10 (produced by the hybridoma having ATCC Accession No. HB-12535), 3H3.14.5 (produced by the hybridoma having ATCC Accession No. HB-12534) and 3D5.1.10 (produced by the hybridoma having ATCC Accession No. HB-12536).
Dependencies are inferred from the claim text.