Method for modularting activity of t lymphocytes
OwnerNathalie Demotte, Peirre Van Der Druggen +1inventors
InventorsNathalie Demotte, Peirre Van Der Druggen, Thierry Boon-Falleur
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Abstract
The invention relates to methods and compositions which modulate T lymphocyte activity. It has been found that two, T lymphocyte receptors, especially TCR and CD8, are present at a distance from each other on T lymphocyte surfaces. Via use of modulators which change the distance between these receptors, the activity of the T lymphocyte is modulated.
Claims22
A method for modulating activity of a T lymphocyte, comprising contacting said T lymphocyte with a substance that changes distance between a T lymphocyte receptor and a T lymphocyte co-receptor to a point sufficient to modulate activity of said T lymphocyte.
A method for determining if a substance modulates activity a T lymphocyte, comprising determining distance between a TCR molecule and a CD8 molecule on said T lymphocyte prior to contact with said substance, followed by determination of said distance after said contact, a difference there between being indicative of a substance which modulates activity of said T lymphocyte.
Composition useful in modulating T cell production comprising at least one peptide which binds to an MHC molecule and a substance which changes distance between a T lymphocyte receptor and co-receptor to a point sufficient to modulate T lymphocyte activity.
Composition useful in modulating T cell production comprising at least one vaccine material and a substance which changes distance between a T lymphocyte receptor and co-receptor to a point sufficient to modulate T lymphocyte activity.
Dependencies are inferred from the claim text.