Method for determining the genotype at the crohn's disease locus
AssigneesUniversite De Liege, Centre Hospitalier Universitaire De Liege, Commissariat a l'Energie Atomique
InventorsMichel Georges, Edouard Louis, Cecile Libioulle, Mark Lathrop
Life of this patent
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Abstract
The present invention refers to a method for determining the genotype of an individual at the 5p13.1 Crohn's disease risk locus, the method comprising: providing a sample from the individual; determining whether a DNA sequence corresponding to a DNA sequence polymorphism located between coordinated 40,300,000 and 40,600,000 of human chromosome (coordinates corresponding to the march 2006 assembly of the human genome) is present in the sample; and determining the nature of the DNA sequence polymorphism genotype located between coordinated 40,300,000 and 40,600,000 of human chromosome as it relates to the genetic risk to develop Crohn's disease.
Claims15
A method for determining the genotype of a human individual at the 5p13.1 Crohn's disease risk locus, the method comprising:
- a) providing a sample from the individual;
- b) determining whether a DNA sequence corresponding to a DNA sequence polymorphism located between coordinated 40,300,000 and 40,600,000 of human chromosome (coordinates corresponding to the march 2006 assembly of the human genome) is present in the sample;
- c) determining the nature of the DNA sequence polymorphism genotype located between coordinated 40,300,000 and 40,600,000 of human chromosome as it relates to the genetic risk to develop Crohn's disease.
A method for judging a possibility of the onset of Crohn's disease, wherein a sample from a human individual is tested, wherein a human individual in which the DNA sequence located between coordinated 40,300,000 and 40,600,000 of human chromosome (coordinates corresponding to the march 2006 assembly of the human genome) contains an allele associated with increased risk for Crohn's disease is judged to have a risk of the onset of Crohn's disease.
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An oligonucleotide for determining the genotype of a human individual at the 5p13.1 Crohn's disease risk locus, selected from the group consisting of:
- a) an oligonucleotide comprising from 12 to 30 contiguous nucleotides of the sequence located between coordinated 40,300,000 and 40,600,000 of human chromosome (coordinates corresponding to the march 2006 assembly of the human genome), wherein said oligonucleotide include one position of the SNPs, and wherein said position is occupied by a nucleotide corresponding to the respective SNPs correlated with the risk of Crohn's disease.
- b) an oligonucleotide which is entirely complementary to the oligonucleotide of (a).
Dependencies are inferred from the claim text.