US 2010/0136540 A1 · Methods and compositions for characterizing patients for clinical outcome trials

Abstract

The invention provides with methods for characterizing and selecting, within a population of subjects with type-2 diabetes, subjects that are suited for clinical trials based on the identification of one or more genetic features, which are single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), and/or other genomic markers. The invention further involves characterizing these subjects based on the probability of developing complications related to type-2 diabetes, such as, myocardial infarction, stroke and albuminuria. Also described are combinations and kits for carrying out the above-described methods.

Claims19

Dependent claims

A method for characterizing a subject for inclusion or exclusion from a clinical trial, comprising detecting, in a sample obtained from said subject, the presence or absence of at least one genetic feature which is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 1, 4, 7, 10, 16 or 19;
(b) at least one SNP which is in linkage disequlibrium with at least one SNP of (a);
or
(c) at least one short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

1 more element

Dependencies are inferred from the claim text.

Facts

Application

12/457,556Filed 15 Jun 2009

Priority

13 Jun 2008

Published

3 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C12Q 1/6883
Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes: for diseases caused by alterations of genetic material
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
C12Q 2600/106
Oligonucleotides characterized by their use: pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/156
Oligonucleotides characterized by their use: polymorphic or mutational markers

Methods and compositions for characterizing patients for clinical outcome trials

Life of this patent

Methods and compositions for characterizing patients for clinical outcome trials

Life of this patent

Abstract

Claims19