Photoreceptor precursor cells
AssigneeThe Regents of the University of Michigan
InventorsAnand Swaroop, Masayuki Akimoto, Alan Mears, Hong Cheng, Edwin C.T. Oh
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Abstract
The present invention relates to photoreceptor cells. In particular, the present invention provides photoreceptor cells comprising heterologous nucleic acid sequences and transgenic animals comprising the same. The present invention also provides photoreceptor precursor cells (e.g., rod photoreceptor precursor cells), and methods of identifying, characterizing, isolating and utilizing the same. Compositions and methods of the present invention find use in, among other things, research, clinical, diagnostic, drug discovery, and therapeutic applications.
Claims21
1-53. (canceled)
A composition comprising a purified photoreceptor precursor cell.
A method screening test compounds comprising:
- a) providing a photoreceptor cell comprising a heterologous nucleic acid sequence encoding a Nrl promoter operatively linked to green fluorescent protein;
- b) exposing said cell to one or more test compounds;
- and
- c) detecting a change in photoreceptor cell function.
A method of converting a non-rod cell to a rod photoreceptor cell comprising altering Nrl expression and/or activity in said non-rod cell.
Dependencies are inferred from the claim text.