Target protein and target gene in drug designing and screening method

A drug for the treatment or prophylaxis of an allergic disease, which comprises a compound selected from the group consisting of the following formulas (I)-(III) or a salt acceptable as a pharmaceutical agent:

• wherein R1 is a hydrogen atom or hydroxy,
• R2 and R3 are each independently phenyl or phenylalkyl having 7 to 11 carbon atoms, each of which is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen, cyano, hydroxy and amino,
• Y1 is any of the groups represented by the following formulas:
• Z1 is a hydrogen atom, or alkyl having 8 to 20 carbon atoms, alkenyl having 8 to 20 carbon atoms, alkyloxy having 8 to 20 carbon atoms or alkylamino having 8 to 20 carbon atoms, each of which is optionally substituted by 1 to 5 substituents selected from the group consisting of halogen, cyano, hydroxy, carbonyl, amino, alkyl having 1 to 5 carbon atoms, alkyloxy having 1 to 5 carbon atoms and cycloalkyl having 3 to 7 carbon atoms;
• wherein R4 is a hydrogen atom, hydroxy or any of the groups represented by the following formulas:
• wherein R6 is alkyl having 1 to 5 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, phenyl, phenylalkyl having 7 to 11 carbon atoms or heterocycle,
• R5 is a hydrogen atom, or alkyl having 1 to 5 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, phenyl or phenylalkyl having 7 to 11 carbon atoms, each of which is optionally substituted by 1 or 2 substituents selected from the group consisting of a halogen atom, cyano, hydroxy and amino,
• Y2 is any of the groups represented by the following formula:
• —N-A- (A is alkyl group having 1 to 3 carbon atoms)
• Z2 is as defined for Z1;
• wherein Z3 is a hydrogen atom, or alkyl having 1 to 7 carbon atoms, alkenyl having 2 to 7 carbon atoms, alkyloxy having 1 to 7 carbon atoms or alkylamino having 1 to 7 carbon atoms, each of which is optionally substituted by 1 to 5 substituents selected from the group consisting of halogen, cyano, hydroxy, carbonyl, amino, alkyl having 1 to 5 carbon atoms, alkyloxy having 1 to 5 carbon atoms and cycloalkyl having 3 to 7 carbon atoms, or R8, wherein R8 is phenyl optionally substituted by 1 to 3 substituents selected from the group consisting of alkyl having 1 to 7 carbon atoms, alkyloxy having 1 to 7 carbon atoms, carboxylic acid, halogen, cyano, hydroxy and amino.