Antibodies useful for therapy and diagnosis of cancer
AssigneeAvir Green Hills Biotechnology Research Developmen
InventorsJohannes Humer, Bernd Mayer, Thomas Muster, Andrea Waltenberger
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Abstract
The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies.
Claims17
An antibody or fragment thereof characterized in that the antibody or fragment thereof has specificity to the same epitopes as an antibody produced by the hybridoma cell line having DSMZ accession number DSM ACC2842 or as an antibody produced by the hybridoma cell line having DSMZ accession number DSM ACC2879.
An antibody or fragment thereof characterized in that it is produced by the hybridoma cell line having DSMZ accession number DSM ACC2842 deposited on May 10, 2007 or by the hybridoma cell line having DSMZ accession number DSM ACC2879 being deposited on Jan. 16, 2008.
An antibody that competes with an antibody produced by the hybridoma cell line having DSMZ accession number DSM ACC2842 or with an antibody produced by the hybridoma cell line having DSMZ accession number DSM ACC2879 for binding to epitopes of an endogenous retrovirus.
A hybridoma cell line deposited as DSM ACC2842 at the DSMZ on May 10, 2007.
A hybridoma cell line deposited as DSM ACC2879 at the DSMZ on Jan. 16, 2008.
A method for isolating and/or identifying regions of an endogenous retrovirus in vitro, characterized in that an antibody or a fragment thereof is used which binds to the same antigen as an antibody which is produced by the hybridoma cell lines having DSMZ accession numbers DSM ACC2842 deposited at the DSM on May 10, 2007 or DSM ACC2879 deposited on Jan. 16, 2008.
Dependencies are inferred from the claim text.