New compositions and methods for cell killing
OwnerShmuel Bukshpaninventor
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Abstract
The present invention discloses an insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment. The invention also provides articles of manufacture comprises the PSS and presents an effective method for killing the LTCs.
Claims34
An insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact;
- the PSS comprising (i) proton source or sink providing a buffering capacity;
- and (ii) means providing proton conductivity and/or electrical potential;
- wherein the PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.
A method for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of said LTC;
- said method comprising steps of
- a. providing at least one PSS having (i) proton source or sink providing a buffering capacity;
- and (ii) means providing proton conductivity and/or electrical potential;
- b. contacting said LTCs with said PSS;
- and,
- c. by means of said PSS, effectively disrupting the pH homeostasis and/or electrical balance within said LTC while efficiently preserving the pH of said LTC's environment.
Dependencies are inferred from the claim text.