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US 2010/0136142 A1Published application
Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof
AssigneeBayer Schering Paharma Aktiengesellschaft
InventorsLars Bärfacker, Peter Kolkhof, Karl-Heinz Schlemmer, Rolf Grosser, Adam Nitsche, Martina Klein, Klaus Münter, Barbara Albrecht-Küpper, Elke Hartmann
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Abstract
The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
Claims13
A compound of the formula (I)
- in which
- D is N or C—R4, in which
- R4 is hydrogen, fluorine, trifluoromethyl or (C1-C4)-alkyl,
- Ar is a group of the formula
- in which
- * is the linkage point,
- R5 is hydrogen, fluorine, chlorine, cyano, nitro, trifluoromethyl or (C1-C4)-alkyl,
- R6 is hydrogen or fluorine,
- R7 is halogen, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy or trifluoromethoxy,
- R8 is cyano or nitro,
- R9 is hydrogen, halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylthio or di-(C1-C4)-alkylamino, it being possible for the alkyl group in said (C1-C4)-alkyl, (C1-C4)-alkoxy and (C1-C4)-alkylthio radicals in each case to be substituted up to three times by fluorine,
- or
- phenyl, which may be substituted by halogen, (C1-C4)-alkyl or trifluoromethyl,
- R10 is hydrogen, halogen or (C1-C4)-alkyl,
- E is CH, C—R7 or N,
- and
- n is the number 0, 1 or 2,
- it being possible in the case where the substituent R7 occurs more than once for its meanings to be identical or different,
- R1 is (C1-C4)-alkyl which may be substituted up to three times by fluorine,
- R2 is (C1-C6)-alkyl which may be substituted by (C3-C7)-cycloalkyl or up to three times by fluorine, or is a group of the formula —SO2—R11 in which
- R11 is (C1-C6)-alkyl, trifluoromethyl, (C3-C7)-cycloalkyl, phenyl or 5- or 6-membered heteroaryl having up to two heteroatoms from the series N, O and/or S,
- it being possible for phenyl and heteroaryl in turn each to be substituted once or twice, identically or differently, by halogen, cyano, nitro, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy and/or trifluoromethoxy,
- and
- R3 is hydrogen, fluorine, trifluoromethyl or (C1-C4)-alkyl,
- and the salts, solvates and solvates of the salts thereof.
22 more elements
(canceled)
Dependencies are inferred from the claim text.