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US 2010/0136135 A1Published application
Method of Selecting Phosphate Binder and its Uses Thereof
AssigneeGloboAsia, L.L.C.
InventorKeith Chan
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Abstract
A method of selecting or determining a candidate compound suitable for use as a phosphate binder is disclosed. The candidate compound includes ferric compounds, ferric compound complexes, and their derivatives, salts, analogs, and metabolites. The effectiveness of the candidate compound as a phosphate binder is evaluated by a method, comprising measuring and correlating reduction of phosphate concentration in solution and reduction of phosphate absorption in cells.
Claims9
A method to determine whether a candidate compound is capable of binding phosphate, comprising steps of:
- contacting the candidate compound with phosphate under conditions permitting binding of the candidate compound with phosphate;
- measuring reduction of phosphate concentration in the presence of the candidate compound in a variety of buffer or solution;
- contacting the candidate compound with Caco-2 cells in a phosphate solution;
- measuring reduction of phosphate absorption in the cell;
- and
- correlating reduction of phosphate concentration in solution with reduction of phosphate absorption in the Caco-2 cells, wherein direct correlation of phosphate reduction indicates that the candidate compound is a phosphate binder.
3 more elements
Dependencies are inferred from the claim text.