Nutritive compositions and methods of using same
AssigneePentec Health, Inc.
InventorsEileen Moore, Stan Lindenfeld, Michelle Ricker
Life of this patent
Estimating the term…
Abstract
The invention provides intradialytic parenteral nutrition (IDPN) solutions with low carbohydrate for the treatment of malnutrition in dialysis patients. The IDPN solutions of the invention are particularly advantageous for the treatment of malnutrition in patients who are diabetic or suffer from other glucose management related pathologies or patients who require strict fluid management.
Claims53
A composition comprising:
- a) between 0.02 and 0.10 g/ml of dextrose;
- and
- b) between 0.10 and 0.20 g/ml of amino acids;
- wherein the dextrose and the amino acids are both dissolved in an aqueous solution.
A dosage form comprising
- a) between 10 and 50 g of dextrose;
- and
- b) between 30 and 120 g of amino acids;
- wherein the dextrose and the amino acids are dissolved in between 100 mL and 2 L of aqueous solution, and wherein the solution is contained within a sterile container, wherein the sterile container is suitable for parenteral administration of the aqueous solution.
A method of treating malnutrition in a hemodialysis patient in need thereof comprising determining a body mass of the patient, wherein if the body mass of the patient is between 34 and 39 kg, the patient is parenterally administered about 20 g of dextrose and about 51 g of amino acids in about 334 mL of solution;
- wherein if the body mass of the patient is between 40 and 44 kg, the patient is parenterally administered about 23 g of dextrose and about 60 g of amino acids in about 383 mL of solution;
- wherein if the body mass of the patient is between 45 and 51 kg, the patient is parenterally administered about 26 g of dextrose and about 68 g of amino acids in about 427 mL of solution;
- wherein if the body mass of the patient is between 52 and 59 kg, the patient is parenterally administered about 30 g of dextrose and about 78 g of amino acids in about 483 mL of solution;
- wherein if the body mass of the patient is between 60 and 69 kg, the patient is parenterally administered about 35 g of dextrose and about 90 g of amino acids in about 550 mL of solution;
- and wherein if the body mass of the patient is above 70 kg, the patient is parenterally administered about 41 g of dextrose and about 105 g of amino acids in about 635 mL of solution;
- thereby treating malnutrition in the hemodialysis patient in need thereof.
A dosage form comprising:
- a) about 20 g of dextrose;
- and
- b) about 51 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 334 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising:
- a) about 23 g of dextrose;
- and
- b) about 60 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 383 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising:
- a) about 26 g of dextrose;
- and
- b) about 68 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 427 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising:
- a) about 30 g of dextrose;
- and
- b) about 78 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 483 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising:
- a) about 35 g of dextrose;
- and
- b) about 90 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 550 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising:
- a) about 41 g of dextrose;
- and
- b) about 105 g of amino acids;
- wherein the dextrose and amino acids are dissolved in an aqueous solution of about 635 mL in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A dosage form comprising an aqueous solution comprising between 0.02 and 0.10 g/ml dextrose and between 0.10 and 0.20 g/ml amino acids wherein the dextrose and amino acids are dissolved in the aqueous solution between 300 mL and 1 L in volume and wherein the dosage form is contained in a sterile container appropriate for parenteral administration of the aqueous solution to a human patient.
A method for treating malnutrition in a patient receiving hemodialysis, the method comprising administering to the patient an aqueous composition comprising between 0.02 and 0.10 g/mL of dextrose and 0.10 and 0.20 g/mL of amino acids, wherein the amount of dextrose and the amount of amino acids administered are dependent upon the mass of the patient.
Dependencies are inferred from the claim text.