Nanoparticle-coated capsule formulation for dermal drug delivery
AssigneeUniversity of South Australia
InventorsClive Allan Prestidge, Spomenka Simovic, Nasrin Ghouchi Eskandar
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Abstract
A method and formulation for the delivery of an active substance to the skin (epidermis, including the stratum corneum and viable epidermis, and dermis) of a subject. The formulation comprises oil-based or aqueous droplets comprising the active substance within a coating of nanoparticles, particularly silica nanoparticles. The active substance may be suitable for the treatment of a disease or condition which is localised, or at least partially localised, to the skin (eg skin cancer, psoriasis, eczema, infections including bacterial and fungal infections, acne, dermatitis, inflammation, and rheumatoid arthritis).
Claims24
A method of dermal delivery of an active substance, said method comprising topically applying to the skin of a subject a formulation comprising droplets of a suitable carrier comprising said active substance and, optionally, an emulsifier, wherein said droplets are coated on their surface with at least one layer of nanoparticles, and wherein said active substance is not retinol or a retinol derivative.
A formulation for topical application to the skin, wherein said formulation comprises droplets of a suitable carrier comprising an active substance and, optionally, an emulsifier, wherein said droplets are coated on their surface with at least one layer of nanoparticles, and wherein said active substance is not retinol or a retinol derivative.
Dependencies are inferred from the claim text.