Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
AssigneeLipocine Inc.
InventorsFENG-JING CHEN, MAHESH V. PATEL, DAVID T. FIKSTAD, HUIPING ZHANG, CHANDRASHEKAR GILIYAR
Life of this patent
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Abstract
The present invention relates to pharmaceutical compositions and methods for improved solubilization of triglycerides and improved delivery of therapeutic agents. Compositions of the present invention include a carrier, where the carrier is formed from a combination of a triglyceride and at least two surfactants, at least one of which is hydrophilic. Upon dilution with an aqueous medium, the carrier forms a clear, aqueous dispersion of the triglyceride and surfactants.
Claims62
A pharmaceutical composition comprising:
- a) a carrier comprising:
- i) a triglyceride;
- ii) at least two surfactants, at least one of the surfactants being a hydrophilic surfactant;
- and
- b) a therapeutically effective amount of a sex hormone;
- wherein the triglyceride and surfactants are present in amounts such that upon mixing with an aqueous solution in an aqueous solution to a composition ratio of about 100:1 by weight, the composition forms a dispersion having an average particle size of less than 200 nm.
A pharmaceutical composition comprising:
- a) a triglyceride;
- b) a carrier comprising at least two surfactants, at least one of the surfactants being hydrophilic;
- and
- c) a therapeutically effective amount of a sex hormone.
A pharmaceutical composition comprising:
- a) a triglyceride;
- b) a hydrophilic alcohol transesterified surfactant;
- and
- c) a therapeutically effective amount of testosterone, or an ester thereof.
A pharmaceutical composition comprising:
- a) a triglyceride;
- b) PEG-35 castor oil, PEG-40 castor oil, PEG-40 hydrogenated castor oil, or a combination thereof;
- and
- c) a therapeutically effective amount of testosterone, or an ester thereof.
A method of providing hormone therapy in a patient comprising orally administering to a patient in need thereof a pharmaceutical composition comprising:
- a) a therapeutically effective amount of sex hormone;
- b) a triglyceride;
- and
- c) a carrier comprising at least two surfactants, at least one of the surfactants being hydrophilic.
Dependencies are inferred from the claim text.