Cosmetic anti-ageing skin care compositions
AssigneeTupperware Products S.A.
InventorsStephanus Cornelis Maria Otte, Claudia Amalia Estrada Hemandez, Annis Won
Life of this patent
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Abstract
The invention is directed to an anti ageing skin care composition, more in particular a cosmetic anti aging skin care composition. The anti ageing skin care composition of the invention comprise, in a physiologically acceptable medium, (i) at least one peptide from Laminin-1 that is able to promote synthesis of Laminin-5; (ii) at least one peptide capable of at least partially inhibiting neuronal exocytosis; and (iii) at least one tripeptide producing a rapid and strong stimulation of collagen synthesis. The compositions of the present invention are effective in reducing existing wrinkles and/or preventing the formation of new wrinkles.
Claims20
Anti-ageing skin care composition, comprising, in a physiologically acceptable medium,
- (i) at least one peptide from Laminin-1 that is able to promote synthesis of Laminin-5;
- (ii) at least one peptide capable of at least partially inhibiting neuronal exocytosis;
- and
- (iii) at least one tripeptide producing a rapid and strong stimulation of collagen synthesis.
The composition according to any of the previous claims, wherein the at least one peptide capable of at least partially inhibiting neuronal exocytosis comprises an amino acid sequence derived from the amino acid sequence of the protein SNAP 25.
The composition according to any one of the preceding claims, wherein the at least one peptide capable of at least partially inhibiting neuronal exocytosis is a hexapeptide, heptapeptide, octapeptide, nonapeptide, or decapeptide.
The composition according to any one of the preceding claims, wherein the at least one peptide capable of at least partially inhibiting neuronal exocytosis is the hexapeptide defined by SEQ. ID No. 2.
The composition according to any of the previous claims, wherein the at least one peptide capable of at least partially inhibiting neuronal exocytosis is chosen from the group consisting of:
- i) a peptide that is substantially homologous with the peptide defined by SEQ ID No. 2;
- a cosmetically acceptable salt of the peptide defined by SEQ ID No. 2;
- and
- iii) a peptide defined by SEQ ID No. 2 that has undergone reversible chemical changes.
The composition according to any of the previous claims, wherein the at least one peptide capable of at least partially inhibiting neuronal exocytosis is chosen from the group consisting of:
- i) a peptide comprising a sequence ranging from 3 to 30 amino acids comprised in SEQ ID No. 1;
- ii) a peptide comprising a sequence ranging from 6 to 19 amino acids derived from the N-terminus of the protein SNAP 25, chosen from the group consisting of the peptides defined by SEQ ID No. 2 and SEQ ID No. 3;
- iii) a peptide comprising a sequence ranging from 6 to 19 amino acids derived from the C-terminus of the protein SNAP 25, chosen from the group consisting of the peptides defined by SEQ ID No. 5 and SEQ ID No. 6;
- iv) a peptide mixture comprising at least one peptide ranging from 3 to 30 amino acids chosen from the group consisting of those described in i), ii) and iii) and at least one peptide ranging from 3 to 30 amino acids comprised in SEQ ID No. 4;
- and
- v) a peptide mixture comprising at least one peptide chosen from the group consisting of the peptides defined by SEQ ID No. 2 and SEQ ID No. 3 and at least one peptide chosen from the group consisting of the peptides defined by SEQ ID No. 5 and SEQ ID No. 6.
The composition according to any one of the preceding claims, wherein the at least one tripeptide producing a rapid and strong stimulation of collagen synthesis is a tripeptide of general formula (II) or any derivative thereof,
- wherein
- R1 represents H, —C(O)—R6, —SO2R6 or —C(O)—XR6
- R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2, n equals 1-4,
- R3 represents linear or branched C1-C4-alkyl that is optionally substituted by hydroxyl,
- R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)-alkyl, optionally substituted (C2-C24-alkenyl, optionally substituted phenyl, optionally substituted phenyl-(C1-C4)-alkyl or 9-fluorenylmethyl,
- X represents oxygen (—O—) or —NH—;
- or
- XR5 with X═O also represents the esters of α-tocopherol, tocotrienol or retinol.
The composition according to any one of the preceding claims, further comprising at least one active agent chosen from the group consisting of a desquamating agent;
- a moisturiser;
- a depigmenting or propigmenting agent;
- an anti-glycation agent;
- an agent for stimulating the synthesis of dermal or epidermal macromolecules and/or for preventing their degeneration;
- an agent for stimulating fibroblasts and/or keratinocytes proliferation or for stimulating keratinocytes differentiation;
- a dermo-relaxant;
- a filling and swelling agent;
- a tightening agent;
- an antipollution agent;
- a free-radical scavenger;
- an agents that acts on capillary circulation;
- and an agent that acts on the energy metabolism of cells.
The composition according to any one of the preceding claims, further comprising at least one adjuvant chosen from the group consisting of a hydrophilic gelling agent, a lipophilic gelling agent, a hydrophilic active agent, a lipophilic active agent, a solvent, a preserving agent, a filler, a fragrance, a screening agent, an odour absorber, a pigment, and a colouring agent.
The composition according to any one of the preceding claims, wherein the composition is in a form chosen from the group consisting of an optionally gelled aqueous solution, a lotion dispersion, optionally a two-phase lotion, an O/W emulsion, an W/O emulsion, a triple emulsion chosen from W/O/W and O/W/O emulsions, an ionic vesicular dispersion, and a non-ionic vesicular dispersion.
The composition according to any one of the preceding claims, further comprising at least one photoprotective agent chosen from the group consisting of UVA-active and UVB-active organic and mineral photoprotective agents.
Composition according to any of the previous claims for improving collagen synthesis reactions of the skin matrix.
Method of cosmetic treatment of the skin, in particular human skin, comprising applying a composition according to any of the previous claims to at least a part of the outer surface of said skin.
Dependencies are inferred from the claim text.