Immunotherapeutic Method For Increasing Groundnut Tolerance In A Subject
AssigneeDBV Technologies
InventorsLucie Mondoulet, Christophe Dupont, Pierre-Henri Benhamou, Bertrand Dupont
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Abstract
The present invention describes a new method for progressive desensitization of a subject to groundnut. More specifically, the invention relates to the immunotherapeutic method for increasing groundnut tolerance in an allergic subject using epicutaneous administration. The present invention is also relative to the use of a skin patch device for progressive desensitization of a subject to groundnut.
Claims25
An immunotherapeutic method for increasing tolerance in a subject to groundnut, comprising:
- repeatedly administering to the subject one or more proteins derived from groundnut via an epicutaneous route using a skin patch including a backing having a periphery adapted to create a hermetically closed chamber when applied to the subject's skin,
- the backing carrying said one or more proteins in a dose sufficient to induce an immune reaction in the subject following application of the skin patch to the subject's skin,
- said one or more proteins being removed from the backing following application of the patch device to the subject's skin and thereafter being delivered to the subject via the epicutaneous route,
- said administration leading, on repetition, to a progressive increase in tolerance in the subject to groundnut.
A method according to claim 18, which method causes an increase in specific IgG4 levels.
A skin patch comprising:
- a backing having a periphery adapted to create a hermetically closed chamber when applied to skin,
- the backing carrying one or more proteins derived from groundnut in a dose sufficient to induce an immune reaction in a subject following application of the skin patch to the subject's skin,
- said one or more proteins derived from groundnut being removed from the backing following application of the skin patch to the subject's skin and thereafter being delivered to the subject via an epicutaneous route.
A method for increasing tolerance to groundnut in a subject in need thereof, comprising repeated epicutaneous administration, on intact skin of said subject, of an adjuvant-free groundnut allergen preparation, said administration allowing said subject to increase his tolerance to groundnut.
A method for preventing or reducing mastocyte degranulation in a subject allergic to groundnut, comprising repeated epicutaneous administration, on intact skin of said subject, of an adjuvant-free groundnut allergen preparation, said administration preventing or reducing mastocyte degranulation in said subject following exposure to groundnut.
A method for reducing lung eosinophilia in a subject allergic to groundnut, comprising repeated epicutaneous administration, on intact skin of said subject, of an adjuvant-free preparation of a groundnut allergen, said administration preventing or reducing lung eosinophilia in said subject following exposure to groundnut.
Dependencies are inferred from the claim text.