Responsive polymeric system
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsDaniel COHN, Alejandro SOSNIK
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Abstract
A novel environmentally responsive polymeric system is provided for biomedical applications, comprising silicon-containing reactive groups which undergo a hydrolysis-condensation reaction at a predetermined body site and thereby change rheological and mechanical properties of the polymeric system. The polymeric system is useful, for example, as a sealant, as a matrix for drug delivery, in the prevention of post-surgical adhesions, and in gene therapy.
Claims29
A responsive polymeric system comprising:
- one or more silicon-containing reactive groups;
- and
- at least one solid component,
- wherein said solid component is a macro, micro or nano-sized material selected from the group consisting of a polymer, a ceramic material, a metal, a carbon, a biological material, and combinations thereof, and
- wherein said solid component is further selected from the group consisting of a particle, a sphere, a capsule, a rod, a slab, a fiber, a mesh, a ribbon, a web, a non-woven structure, a fabric, an amorphous lattice structure, a filament wound structure, a honeycomb structure or a braided structure, and combinations thereof,
- in which said responsive polymeric system is capable of application as a liquid at body temperature to a predetermined body site and upon application to said body site is capable of undergoing a hydrolysis-condensation reaction primarily at said body site in the presence of water and at body temperature, whereby as a result of said hydrolysis-condensation reaction molecular weight of said polymeric system increases due to polymerization and/or crosslinking, and rheological and mechanical properties of said polymeric system are changed.
A responsive polymeric system capable of being used as a sealant, coating, lubricant, a transient barrier, and/or a matrix comprising:
- one or more silicon-containing reactive groups;
- and
- at least one solid component, wherein said solid component is a macro, micro or nano-sized material selected from the group consisting of a polymer, a ceramic material, a metal, a carbon, a biological material, and combinations thereof, and wherein said solid component is further selected from the group consisting of a particle, a sphere, a capsule, a rod, a slab, a fiber, a mesh, a ribbon, a web, a non-woven structure, a fabric, an amorphous lattice structure, a filament wound structure, a honeycomb structure or a braided structure, and combinations thereof, in which said responsive polymeric system is capable of application as a liquid at body temperature to a predetermined body site and upon application to said body site is capable of undergoing a hydrolysis-condensation reaction primarily at said body site in the presence of water and at body temperature, whereby as a result of said hydrolysis-condensation reaction molecular weight of said polymeric system increases due to polymerization and/or crosslinking, and rheological and mechanical properties of said polymeric system are changed.
A responsive polymeric system comprising:
- at least one block copolymer, wherein said block copolymer is polyethylene oxide (PEO) and polypropylene oxide (PPO);
- at least one silicon-containing reactive group, wherein said group is (3-isocyanatopropyl)triethoxysilane;
- and at least one solid ceramic material, in which said responsive polymeric system is capable of application as a liquid at body temperature to a predetermined body site and upon application to said body site is capable of undergoing a hydrolysis-condensation reaction primarily at said body site in the presence of water and at body temperature, whereby as a result of said hydrolysis-condensation reaction molecular weight of said polymeric system increases due to polymerization and/or crosslinking, and after a predetermined period of time said polymerized and/or crosslinked polymeric system is capable of reverting to an un-polymerized or non-crosslinked state.
Dependencies are inferred from the claim text.