Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis
AssigneeInfectious Disease Research Institute
InventorsYasuyuki Goto, Steven G. Reed
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Abstract
Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.
Claims11
An isolated fusion polynucleotide encoding a fusion polypeptide, wherein the fusion polypeptide comprises an immunogenic portion of at least two Leishmania antigens selected from the group consisting of KMP11, SMT, A2 and CPB, or sequences having at least 90% identity thereto.
Dependencies are inferred from the claim text.