Novel shigella protein antigens and methods
AssigneeInternational Vaccine Institute
InventorsCECIL CZERKINSKY, DONG WOOK KIM
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Abstract
The present invention relates to protein antigens IcsP2 and SigA2 from Shigella that are common among numerous Shigella types and species and which can protect against shigellosis or other enteric infections when administered as vaccines. In addition, the present invention relates to antigens that are in common between Shigella species and enteroinvasive Escherichia coli (EIEC). The invention also relates to the use of antibodies raised against these antigens and of DNA probes for use in the diagnosis of Shigella and EIEC infections.
Claims10
A conjugate molecule comprising an O-specific polysaccharide antigen of Shigella bacteria covalently bound to the Shigella IcsP2 or SigA2 protein.
A conjugate molecule comprising a saccharide compound comprising an O antigen of Shigella bacteria covalently bound to an isolated polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:2.
A conjugate molecule comprising a polysaccharide from a bacteria non related to the genus Shigella covalently bound to the Shigella IcsP2 or SigA2 protein.
A conjugate molecule comprising a polysaccharide from a bacteria non related to the genus Shigella covalently bound to an isolated polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.