Combination gas vaccines and therapeutics
AssigneeNovartis AG
InventorsGuido GRANDI, Immaculada MARGARIT Y ROS, Sabrina CAPO, Giuliano BENSI, Andrea Guido Oreste MANETTI
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Abstract
Compositions useful for reducing the risk of, preventing, and/or treating S. pyogenes (GAS) infections which comprise combinations of GAS antigens, nucleic acid molecules encoding the antigens, or antibodies which specifically bind to the antigens.
Claims20
A composition comprising:
- (a) a purified Spy0269 protein comprising the amino acid sequence SEQ ID NO:177;
- (b) a purified mutant Spy0167 protein comprising the amino acid sequence SEQ ID NO:125;
- and
- (c) a purified mutant Spy0416 protein comprising the amino acid sequence SEQ ID NO:198.
A method of treating or reducing risk of infection by Streptococcus pyogenes, administering to an individual in need thereof an effective amount of a composition comprising:
- (a) a purified Spy0269 protein comprising the amino acid sequence SEQ ID NO:177;
- (b) a purified mutant Spy0167 protein comprising the amino acid sequence SEQ ID NO:125;
- and
- (c) a purified mutant Spy0416 protein comprising the amino acid sequence SEQ ID NO:198.
A method of making a vaccine for treating Streptococcus pyogenes infection, comprising combining:
- (a) a purified Spy0269 protein comprising the amino acid sequence SEQ ID NO:177;
- (b) a purified mutant Spy0167 protein comprising the amino acid sequence SEQ ID NO:125;
- (c) a purified mutant Spy0416 protein comprising the amino acid sequence SEQ ID NO:198;
- and
- (d) a pharmaceutically acceptable carrier.
An isolated host cell comprising at least one nucleic acid molecule which encodes:
- (a) a Spy0269 protein comprising the amino acid sequence SEQ ID NO:177;
- and
- (b) a mutant Spy0167 protein comprising the amino acid sequence SEQ ID NO:125;
- and
- (c) a mutant Spy0416 protein comprising the amino acid sequence SEQ ID NO:198.
Dependencies are inferred from the claim text.