Method for modulating atherosclerosis
OwnerDaniel S. Greenspan, William J. Burlinghaminventors
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Abstract
Immunoreactivity to collagen V is associated with development of atherosclerosis. Methods disclosed herein for modulating atherosclerosis and reducing an effect thereof, involve inducing immunological tolerance to collagen V. Methods for evaluating a risk of an individual to develop atherosclerosis and methods for diagnosing atherosclerosis are disclosed herein.
Claims14
A method for reducing atherosclerosis or an effect thereof in an individual having atherosclerosis, the method comprising the steps of:
- inducing immunological tolerance to collagen V in the individual;
- and
- observing reduced atherosclerosis or a reduced effect thereof in the individual.
A method for assessing a risk of an individual to develop atherosclerosis, the method comprising the steps of:
- ascertaining whether the individual is immunoreactive to collagen V;
- and
- assessing the risk of the individual, whereby immunoreactivity is associated with a higher risk than would be expected in an individual from whom immunoreactivity is not observed.
The method of claim 13, wherein the measuring step comprises evaluating peripheral blood mononuclear cells in a delayed-type hypersensitivity assay.
Dependencies are inferred from the claim text.