US 2010/0135980 A1 · Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging, disorders of aging, cancer, as growth factors, and as an alternative to stem cell therapy

Abstract

A method for the treatment and prophylaxis of diseases or conditions associated with aging which includes oxidative stress and cancer. Such diseases or conditions are associated with a decrease or increase presence of one or a combination of one or more Carbonic Anhydrase isozymes I TO VII in the tissue of a subject. These diseases include but are not limited to chronic neurodegenerative diseases such as Alzheimer's disease, parkinson's disease, multiple sclerosis, autism, lou gehrig's disease, huntington's disease, immune disorders which includes systemic lupus erythematosus, diabetes mellitus; musculo-skeletal disorders which includes osteoporosis,arthritis, osteomalacia. Cancer which includes the breast, lung, colon, prostate gland, ovary, esophagus, liver, rectum. The method comprises administering to the patient a pharmaceutically effective non toxic amount of one or a combination of one or more compounds that increases or decreases the level of one or more Cell Specific Carbonic Anhydrase Enzymes whose levels have been increased or decreased in the tissue of the subject. Such compound maybe the Cell Specific Carbonic Anhydrase Enzymes I to VII. A compound that when absorbed reacts or dissociates to form cell specific carbonic enzymes or one or more compounds that when administered promotes the increase or decrease level of one or more cell specific Carbonic anhydrase I,II,III,IV,V,VI,VII. As growth factors of stem cells as an alternative to stem cell therapy. These methods includes the administering of one or a combination of one or more of these compounds over an extended period of time ranging from 6 months until the patient dies.

Claims20

Dependent claims

A method for the prophylaxis and treatment of one or a combination of one or more aging conditions or disorders including cancer in a human patient comprising:

(a) Assaying for the increase or decrease level of one or a combination of one or more Cell Specific Carbonic Anhydrase CA)-I, (CA)-II, (CA)-III, (CA)-IV, (CA)-V, (CA)-VI and (CA)-VII in the tissue of a human patient suspected of having a condition of cancer which includes cancer of the breast, the colon, the prostate, the rectum, the pancreas, the lung, the ovary, the testis, the esophagus, the liver
(b) Assaying for the decreased level of one or a combination of one or more cell specific carbonic anhydrase enzymes(CA)-I, (CA)-II, (CA)-III, (CA)-IV, (CA)-V, (CA)-VI and (CA)-VII in a subject suspected of a condition of aging which includes chronic neurodegenerative disorders;
immune disorders;
muskulo-skeletal disorders, cardio-vascular disorders, disorders of the reproductive system, integumentary disorders;
endothelial disorders;
astro-intestinal disorders, genito-urinary tract disorders, amyloid disorders;
myopathies
(c) selecting the human patient whose assay shows an increase in the level of one or a combination of one or more cell specific carbonic anhydrase enzymes I to VII
(d) selecting the patient whose assay shows a decrease in the level of one or a combination of one or more cell specific carbonic enzymes I to VII.
then
(e) Administering to the patient a pharmaceutically effective non-toxic amount of one or a combination of one or more Cell specific Carbonic anhydrase enzymes (CA)-I, (CA)-II, (CA)-III, (CA)-IV, (CA)-V, (CA)-VI, and (CA)-VII whose levels are decreased in the tissue of a human patient.
(f) Administering to the patient a pharmaceutically effective non toxic amount of one or a combination of one or more inhibitors of cell specific carbonic anhydrase Enzyme (CA)-I, (CA)-II, (CA)-III, (CA)-IV, (CA)-V, (CA)-VI and (CA)-VII whose levels are increased in the tissue of the human patient.

9 more elements

Dependencies are inferred from the claim text.

Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging, disorders of aging, cancer, as growth factors, and as an alternative to stem cell therapy

Life of this patent

Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging, disorders of aging, cancer, as growth factors, and as an alternative to stem cell therapy

Life of this patent

Abstract

Claims20