Methods for the treatment of renal failure
AssigneeHadasit Medical Research Services and Development Ltd.
InventorsJonathan Axelrod, Daniel Barkan, Eithan Galun, Yael Nehemia, Stefan Rose-John
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Abstract
The present invention relates to methods for treating renal failure. Particularly, the present invention relates to methods for treating renal failure by administering to a subject complexes that include a member of the IL-6 family linked to a soluble receptor of the member of the IL-6 family, or isolated polynucleotides encoding same, the complexes capable of activating a gp130 mediated signaling pathway, thereby treating acute or chronic renal failure.
Claims21
-34. (canceled)
A method for treating renal failure in a subject which comprises administering to the subject a therapeutically effective amount of an active agent of (a) a complex comprising IL-6/soluble IL-6 receptor (sIL-6R) or a biologically active analog, fragment, or salt thereof, (b) an isolated polynucleotide encoding a complex comprising IL-6/soluble IL-6 receptor (sIL-6R) or a biologically active analog or fragment thereof, (c) an expression vector comprising an isolated polynucleotide encoding a complex comprising IL-6/soluble IL-6 receptor (sIL-6R) or a biologically active analog or fragment thereof, or (d) a host cell, the host cell transfected with an expression vector comprising an isolated polynucleotide encoding a complex comprising IL-6/soluble IL-6 receptor (sIL-6R) or a biologically active analog or fragment thereof, thereby treating the renal failure.
Dependencies are inferred from the claim text.