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US 2010/0135901 A1Published application
Combination therapy
OwnerNiels Peter Hundahl Moller, Kresten Skak +1inventors
InventorsNiels Peter Hundahl Moller, Kresten Skak, Jørn Roland Müller
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Abstract
The invention provides combination treatments with IL-21, analogues and derivatives thereof.
Claims21
A composition comprising a combination of
- (a) a first component selected from the group consisting of human IL-21, an analogue of IL-21, and a derivative of IL-21;
- (b) a second component selected from the group consisting of:
- (i) a radiopharmaceutical selected from the group consisting of Cesium-137, Iridium-192, Americium-241, Gold-198, Cobalt -57, Copper-67, Technetium-99, Iodide-123, Iodid-131 and Indium-111;
- (ii) a cell-cycle regulator or apoptosis-inducing agent, wherein the second component is selected from the group consisting of cdc-25, NSC 66384, flavopiridol, 7-hyroxystaurosporine, roscovitine, and BIBR1532 XOT-095;
- and
- (iii) an anti-angiogenesis drug selected from the group consisting of avastin, neovastat, thalidomide, PTK787, ZK222584, ZD-6474, SU6668, PD547,632 VEGF-Trap, CEP-7055, NM-3, and SU11248.
3 more elements
A composition comprising a combination of
- (a) a first component selected from the group consisting of human IL-21, an analogue of IL-21, and a derivative of IL-21;
- (b) a second component comprising IFN-α;
- and
- (c) a third component comprising thymopentin.
1 more element
A composition comprising a combination of
- (a) a first component selected from the group consisting of human IL-21, an analogue of IL-21, and a derivative of IL-21;
- (b) a second component comprising cis-platin;
- and
- (c) a third component comprising IFN-α.
1 more element
A composition comprising a combination of
- (a) a first component selected from the group consisting of human IL-21, an analogue of IL-21, and a derivative of IL-21;
- (b) a second component selected from the group consisting of Vinblastine, DTIC, Fotemustine, Gemcitabine;
- and
- (c) a third component comprising IFN-α.
1 more element
Dependencies are inferred from the claim text.