A combination of two contrast agents, provided for application in a CT examination with at least two different discretely examined X-ray energy spectra for assessing the proportion of a first and a second tissue type or material, with a connecting line with a base gradient being formed between the first and second tissue type or material in an HU value diagram of the X-ray energy spectra, the combination comprising:
- a first contrast agent having a gradient in respect of the at least two energy spectra in an HU value diagram, the gradient being significantly greater than the base gradient;
- and
- a second contrast agent having a gradient in respect of the at least two energy spectra in the HU value diagram, the gradient lying in a significance region of the base gradient.