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US 2010/0134605 A1Published application
In vivo spectral micro-imaging of tissue
AssigneesLawrence Livermore National Security, LLC, The Regents of the University of California
InventorsStavros G. Demos, Shiro Urayama, Bevin Lin, Ramez Moussa Ghobrial Saroufeem
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Abstract
In vivo endoscopic methods an apparatuses for implementation of fluorescence and autofluorescence microscopy, with and without the use of exogenous agents, effectively (with resolution sufficient to image nuclei) visualize and categorize various abnormal tissue forms.
Claims29
A method, comprising:
- illuminating target tissue with ultraviolet (UV) light having a wavelength of less than 400 nm to produce fluorescense;
- providing imaging optics capable of producing microscopic resolution within a range from about 0.2 μm to about 5 μm, wherein a portion of said flourescense is directed toward said imaging optics to produce directed flourescense;
- optically collecting, with said imaging optics, substantially all of said directed fluorescense to produce collected fluorescense;
- and
- producing an image from said collected fluorescense.
2 more elements
An apparatus, comprising:
- means for illuminating target tissue with ultraviolet (UV) light having a wavelength of less than 400 nm to produce fluorescense ;
- imaging optics capable of producing microscopic resolution within a range from about 0.2 μm to about 5 μm, wherein said imaging optics are fixed such that a portion of said flourescense is directed toward said imaging optics to produce directed flourescense, wherein said imaging optics substantially collect all of said directed fluorescense to produce collected fluorescense;
- and
- means for producing an image from said collected fluorescense.
1 more element
Dependencies are inferred from the claim text.