Biomedical devices containing internal wetting agents

The silicone hydrogel of claim 14 wherein said hydrophilic polymer is selected from the group consisting of polyamides, polylactones, polyimides, polylactams, functionalized polyamides, functionalized polylactones, functionalized polyimides, functionalized polylactams, and mixtures thereof.

The silicone hydrogel of claim 14 wherein said hydrophilic polymer is selected from the group consisting of poly-N-vinyl pyrrolidone, poly-N-vinyl-2-piperidone, poly-N-vinyl-2-caprolactam, poly-N-vinyl-3-methyl-2- caprolactam, poly-N-vinyl-3-methyl-2-piperidone, poly-N-vinyl-4-methyl-2- piperidone, poly-N-vinyl-4-methyl-2-caprolactam, poly-N-vinyl-3-ethyl-2- pyrrolidone, and poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N-N-dimethylacrylamide, polyvinyl alcohol, polyacrylic acid, polyethylene oxide, poly 2 ethyl oxazoline, heparin polysaccharides, polysaccharides, mixtures and copolymers thereof

The hydrogel of claim.20 wherein said oxygen permeable component is present in an amount of 0 to about 80 weight %.

The hydrogel of 20 wherein said oxygen permeable component is present in an amount of about 5 to about 60%.

A method comprising the steps of (a) mixing at least one diluent which is water soluble at processing conditions and reactive components comprising at least one high molecular weight hydrophilic polymer, at least one siloxane containing macromer and an effective amount of at least one compatibilizing component to form a reaction mixture and (b) curing the product of step (a) to form a biomedical device;

• (c) removing said biomedical device from a mold in which said biomedical device was cured and (d) hydrating said biomedical device, wherein both steps (c) and (d) are performed in aqueous solutions which comprise water as a substantial component.

(canceled)

(canceled)

The method of claim 5350 wherein said curing is conducted via heat, exposure to radiation or a combination thereof and said reaction mixture further comprises at least one initiator.

The method of claim 5350 wherein said reaction mixture is cured in a mold and said method further comprises the step deblocking said ophthalmic device from said mold.

A method comprising the steps of (a) mixing reactive components comprising a high molecular weight hydrophilic polymer and an effective amount of a compatibilizing component and (b) curing the product of step (a) at or above a minimum gel time, to form a wettable biomedical device.

A method for improving the wettability of an ophthalmic device formed from a reaction mixture comprising adding at least one high molecular hydrophilic weight polymer and a compatibilizing effective amount of at least one compatibilizing component to said reaction mixture, wherein said compatibilizing component is not a styrene functionalized prepolymer made from hydroxyl functional methacrylates.

An ophthalmic lens comprising a silicone hydrogel which has, without surface treatment, a tear film break up time of at least about 7 seconds

A silicone hydrogel contact lens comprising at least one oxygen permeable component, at least one compatibilizing component and an amount of high molecular weight hydrophilic polymer sufficient to provide said device, without a surface treatment, with tear film break up time after about one day of wear of at least about 7 seconds.

A device comprising a silicone hydrogel contact lens which is substantially free from surface deposition without surface modification.