Back to results
US 2010/0130481 A1Published application
Anticonvulsant and anxiolytic methods of using receptor subtype selective agents
OwnerJames M. Cook, Qi Huang +4inventors
InventorsJames M. Cook, Qi Huang, Xiaohui He, Xioeyan Li, Jianming Yu, Dongmel Han
Life of this patent
Estimating the term…
Abstract
Methods of using orally active benzodiazepine derivatives and their salts are disclosed. These compounds and their salts have anticonvulsant and anxiolytic activity with reduced sedative, hypnotic, muscle relaxant, or ataxic effects.
Claims6
A method for the treatment and/or prevention of convulsions comprising:
- administering to a mammalian subject in need of such treatment an effective amount of a compound of formula VIII, or a salt thereof,
- wherein X is N or CH;
- Y and Z are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(8) position with at least the substituent —C≡C—R, where R is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R1 is H, CH3, CF3, CH2CH3, CH2CF3, or cyclopropyl;
- R2 is a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted, the substituent is F, Cl, Br, or NO2 at the 2′-position.
2 more elements
A method for the treatment and/or prevention of anxiety comprising:
- administering to a mammalian subject in need of such treatment an effective amount of a compound of formula VIII, or a salt thereof,
- wherein:
- X is N or CH;
- Y and Z are taken together with the two intervening carbon atoms to form a ring selected from phenyl and thienyl, which ring is substituted at the C(8) position with at least the substituent —C≡C—R, where R is H, Si(CH3)3, t-butyl, isopropyl, methyl, or cyclopropyl;
- R1 is H, CH3, CF3, CH2CH3, CH2CF3, or cyclopropyl;
- R2 is a substituted or unsubstituted at least partially unsaturated 5 or 6 membered cyclic or heterocyclic ring, wherein if substituted, the substituent is F, Cl, Br, or NO2 at the 2′-position.
3 more elements
Dependencies are inferred from the claim text.