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US 2010/0120105 A1Published application
Carbon pathway optimized production hosts for the production of isobutanol
AssigneeButamax(Tm) Advanced Biofuels LLC
InventorsLarry Cameron Anthony, Michael Dauner, Gail K. Donaldson, Brian James Paul
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Abstract
A microbial host cell is provided for the production of isobutanol. Carbon flux in the cell is optimized through the Entner-Doudoroff pathway.
Claims21
A recombinant microbial host cell comprising a functional or enhanced EDP and an isobutanol production pathway wherein said functional or enhanced EDP provides for increased isobutanol production as compared to the same host cell without said functional or enhanced EDP.
A recombinant microbial host cell comprising an isobutanol production pathway and at least one of the following:
- a) at least one recombinant DNA molecule encoding an enzyme of the EDP;
- b) a disruption in the expression of at least one enzyme of the EMP;
- or
- c) a disruption in the expression of at least one enzyme of the PPP;
- wherein production of isobutanol by said host cell is enhanced by at least 10% as compared to the same host cell without one of (a)-(c).
2 more elements
14-18. (canceled)
Dependencies are inferred from the claim text.