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US 2010/0111998 A1Published application
Hiv vaccines based on env of multiple clades of hiv
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human, Service
InventorsGary J. Nabel, Bimal Chakrabarti, Wing-pui Kong, Yue Huang, Zengguang Wang, Zhi-yong Yang
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Abstract
In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single Glade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.
Claims4
-3. (canceled)
A composition comprising:
- (i) a plasmid comprising SEQ ID NO:
- 24,
- (ii) a plasmid comprising SEQ ID NO:
- 25,
- (iii) a plasmid comprising SEQ ID NO:
- 26,
- (iv) a plasmid comprising SEQ ID NO:
- 27,
- (v) a plasmid comprising SEQ ID NO:
- 28, and
- (vi) a plasmid comprising SEQ ID NO:
- 29,
- and a pharmaceutically acceptable carrier.
10 more elements
Dependencies are inferred from the claim text.