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US 2010/0104641 A1Published application
Therapeutic composition, and use of a cell-free substance
AssigneeStiftung Caesar
InventorsMichael Thie, Oezer Degistirici
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AssigneeStiftung Caesar
InventorsMichael Thie, Oezer Degistirici
Estimating the term…
The invention relates to a therapeutic composition, a method for producing a therapeutic composition, and the use of a cell-free substance, especially a cell-free bone or cartilage matrix. The disclosed therapeutic composition comprises at least a cell-free substance obtained from stimulated stem cells and/or precursor cells. Immunogenic reactions during in vivo therapeutic use are prevented by the fact that the therapeutic composition is free from cells and contains no typically antigenic cell components. The disclosed composition can therefore be universally used for the therapeutic purposes regardless of the origin of the stem cells and/or precursor cells and utilize the natural regenerative potency thereof in a highly efficient manner for replacing tissue, e.g. for a suitable bone and/or cartilage structure.
A therapeutic composition comprising at least a cell-free substance obtained from stimulated stem cells and/or precursor cells.
A method for producing a therapeutic composition comprising stem cells and/or precursor cells that are isolated, cultivated in vitro and stimulated for subsequent differentiation, wherein after differentiation, said cells are killed and/or at least partially removed for producing a cell-free substance, and wherein said cell-free substance is prepared for therapeutic use.
Tissue replacement therapy comprising administering to a patient in need thereof an amount of a cell-free substance effective to enable or support an effective tissue replacement therapy.
Tissue replacement therapy comprising administering to a patient in need thereof an amount of a cell-free cell extract and/or cell secretion effective to enable or support an effective tissue replacement therapy.
Tissue replacement therapy comprising administering to a patient in need thereof an amount of cell-free bone or cartilage matrix effective to enable or support an effective tissue replacement therapy.
Dependencies are inferred from the claim text.