DETECTION OF VON-WILLEBRAND FACTOR (vWF) ACTIVITY
OwnerNancy Cauwenberghs, Karen Vanhoorelbeke +1inventors
InventorsNancy Cauwenberghs, Karen Vanhoorelbeke, Hans Deckmyn
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Abstract
The present invention relates to a method for detecting von-Willebrand factor (vWF) activity comprising assaying a sample in the presence of a soluble form or portion of glycoprotein Ib(α) (GPIb(α)) and ristocetin, or a functionally equivalent substance. Additionally, the invention relates to the use of the aforementioned soluble form or portion of glycoprotein Ib(α), of ristocetin or a functional equivalent substance, of specifically reacting anti-GPIB(α) antibody(ies) and/or of specific binding partners, like specifically reacting anti-vWF antibody(ies) for carrying out the method of the invention. Furthermore, the present invention relates to kits for carrying out the method of the invention.
Claims13
-2. (canceled)
A kit for determining von Willebrand factor (vWF) ristocetin cofactor activity, comprising:
- a soluble form or portion of glycoprotein 1bα (GP1bα) that is not associated with a platelet;
- an anti-GP1bα antibody bound to a solid support;
- an anti-von Willebrand Factor (WF) antibody;
- and
- ristocetin or a functionally equivalent substance.
Dependencies are inferred from the claim text.