Vaccine compositions against infectious pathologies for mammals
AssigneeIrd
InventorFrancisco VEAS
Life of this patent
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Abstract
The invention concerns immunogenic compositions prepared from preparations obtained by incubating first means expressing the target receptor(s) of an infectious pathogenic agent, with second means expressing at least the regions of the infectious pathogenic agent recognising said targets, in conditions enabling interaction between the first and second means so as to form a complex, the incubation being carried out according to different time intervals, and contacting the resulting complexes with a binding agent, for different time intervals, said first and second means being tolerated by mammals. The invention is useful for preparing vaccine compositions designed for mammals against an infectious pathology.
Claims27
An immunogenic composition, wherein the composition is created from preparations obtained by:
- (a) incubation of first cells expressing target receptor(s) of an infectious pathogenic agent, causing infections in a mammal by bonding and then fusion with target cells, with second cells expressing at least regions of the infectious pathogenic agent recognizing the said target receptor(s) under conditions enabling interaction of said first cells and said second cells so as to form a complex, this incubation step being done with different intervals in order to produce complexes corresponding to different fusion stages, and
- (b) putting the complexes formed into contact with a binding agent for different intervals, in order to bind complexes with different exposures and conformations of epitopes against which antibodies are to be formed, the said first cells and said second cells being tolerated by mammals.
An immunogenic composition for forming serum or antibody recognizing an infectious pathogenic agent, wherein the composition is created from preparations obtained by:
- (a) incubation of first cells expressing target receptor(s) of an infectious pathogenic agent, causing infections in a mammal by bonding and then fusion with target cells, with second cells expressing at least regions of the infectious pathogenic agent recognizing the said target receptor(s) under conditions enabling interaction of said first cells and said second cells so as to form a complex, this incubation step being done with different intervals in order to produce complexes corresponding to different fusion stages, and
- (b) putting the complexes formed into contact with a binding agent for different intervals, in order to bind complexes with different exposures and conformations of epitopes against which antibodies are to be formed, the said first cells and said second cells being tolerated by mammals.
Dependencies are inferred from the claim text.