Compositions and methods for blood-brain barrier delivery in the mouse

Abstract

The invention provides compositions and methods, for increasing transport of CNS-active agents across the blood brain barrier in a mouse, e.g., a mouse model of a human CNS condition, while allowing their activity once across the barrier to remain substantially intact. The CNS-active agents are transported across the blood brain barrier via the mouse transferrin receptor. In some embodiments the agents are therapeutic, diagnostic, or research agents.

Dependencies are inferred from the claim text.