Suspension for visualization of transparent tissue in eye
AssigneeSenju Pharmaceutical Co., Ltd.
InventorKeiichi Matsuhisa
Life of this patent
Estimating the term…
Abstract
Disclosed is an ocular transparent tissue-visualizing suspension which can be used as an easy-to-handle and sufficiently safe means to enhance visibility of transparent tissues of the eye during a surgical operation on them. The ocular transparent tissue-visualizing suspension comprises, in an aqueous medium, fine particles of a biodegradable macromolecular compound and at least one salt selected from the groups consisting of salts of trivalent metals and salts of divalent metals.
Claims22
An ocular transparent tissue-visualizing suspension comprising, in an aqueous medium, fine particles of a biodegradable macromolecular compound and at least one salt selected from the group consisting of salts of divalent metals and salts of trivalent metals, wherein the composition is designed to be infused into the eye to be brought into contact with transparent tissues of the eye to enhance the visibility thereof.
A method for preparation of an ocular transparent tissue-visualizing suspension comprising the steps of
- providing a solid preparation comprising fine particles of a biodegradable macromolecular compound,
- providing an aqueous solution containing at least one salt selected from the group consisting of salts of trivalent metals and salts of divalent metals, wherein the concentration of the salt of a trivalent metal is not less than 0.01 w/v %, and/or wherein the concentration of the salt of a divalent metal is not less than 0.1 w/v %, and
- suspending the fine particles in the aqueous solution.
A method for preparation of an ocular transparent tissue-visualizing suspension comprising the steps of
- providing a solid preparation comprising fine particles of a biodegradable macromolecular compound and at least one salt selected from the group consisting of salts of trivalent metals and salts of divalent metals, and
- forming a suspension by mixing the solid preparation with an aqueous medium so that the concentration of the salt of a trivalent metal is not less than 0.01 w/v % and/or the concentration of the salt of a divalent metal is not less than 0.1 w/v %.
An ophthalmic transparent tissue-visualizing preparation comprising a solid preparation comprising fine particles of a biodegradable macromolecular compound and an aqueous medium, separately and kept from contact with each other, wherein the aqueous medium and/or the solid preparation contains a salt of a trivalent metal and/or a salt of divalent metal so that a suspension obtained by mixing the solid preparation with the aqueous medium contains the salt of the trivalent metal at a concentration of not less than 0.01 w/v % and/or the salt of the divalent metal at a concentration of not less than 0.1 w/v %.
Dependencies are inferred from the claim text.